“Getting tired and worn-out makes you age, and being exhausted makes you ugly” is a true portrayal of the current Chinese youth. So, what is the scientific principle behind fatigue leading to aging? What scientific research results and skincare products can accurately address this demand?
On July 19th, the “2024 China Women’s Anti-Fatigue Aging Technology Forum,” hosted by the Chinese Anthropological Society’s Professional Committee for Skin Health and organized by CHANDO, a leading beauty brand in China, in collaboration with experts from Huashan Hospital affiliated with Fudan University and the School of Life Sciences at Fudan University, was held in Shanghai. This forum revealed for the first time the causes of the trend of rejuvenating aging in Chinese women and fatigue-induced aging, providing guidance for research in the field of anti-aging cosmetics in China.
At the same time, CHANDO made a major announcement at the forum by introducing cutting-edge breakthrough technology in “anti-fatigue aging” – the self-developed polar yeast HiMurchaSin® fermentation filtrate and cytoplasmic components. They also proposed the concept of cellular-level rejuvenation and a fundamental solution to anti-fatigue aging for the first time, setting a new benchmark for exploring skin anti-aging in the Chinese beauty industry.
“Fatigue-induced aging” has become a new trend in anti-aging research.
According to the “Report on Changing Trends in Skin Aging among Chinese Women” published by CBNData, the younger generation is becoming more aware of aging at an earlier stage, with 94% of post-2000 generation individuals experiencing skin aging before the age of 25. Among the causes of premature skin aging, 93% of consumers believe it is closely related to unhealthy lifestyles, including sleep problems, excessive competition in life, work pressure, and changes in dietary patterns. Additionally, 80% of respondents believe there is an increase in sleep problems, 56% believe there is an increase in life competition and anxiety, and 50% believe there is an increase in work pressure. Compared to 3-5 years ago, young people are experiencing a comprehensive outbreak of sleep, diet, and stress-related issues.
It is worth mentioning that nearly 90% of consumers also believe that poor sleep can lead to skin problems, accelerating the appearance of wrinkles, sagging, and excessive oil production. Furthermore, 91% of consumers believe that stress accelerates skin aging issues, resulting in increased fine lines and decreased radiance.
It is evident that consumers generally believe that “fatigue leads to skin aging,” and scientific research supports this notion.
According to People’s Daily, Dr. Wang Sijia, a researcher at the Institute of Nutrition and Health, led a team in conducting a systematic analysis of quantified big data on facial skin aging among over 300,000 women from 32 provinces in China. They identified the acceleration inflection points for various facial aging phenotypes and found statistical evidence supporting the trend of younger skin aging among Chinese women. Additionally, the team compared different groups under mental stress and found that mental stress may regulate the expression of key skin cell factors by reducing DNA methylation levels, leading to skin dullness.
The latest research conducted by scientists at CHANDO’s research center reveals that the inflection point for skin aging in Chinese women has advanced by approximately two years in the past three years. Facial aging phenotypes such as crow’s feet, nasolabial folds, and tear troughs are showing a noticeable acceleration between the ages of 24 and 33.
With the high pressure of “996” and “007” work culture, coupled with irregular diet habits, lack of exercise, life stress, and anxiety, fatigue-induced skin aging has become the leading culprit for modern Chinese individuals’ skin. Therefore, understanding the scientific principles behind fatigue-induced skin aging can contribute to the rapid development of anti-aging cosmetics.
During the forum, Dr. Jiang Min, Deputy Chief Physician in the Department of Dermatology at Huashan Hospital affiliated with Fudan University, delivered a presentation titled “Research Progress in Skin Aging and Molecular Target-Based Anti-Aging Strategies.” He stated that skin aging is primarily influenced by endogenous factors (such as genetics, nutrition, fatigue, anxiety) and exogenous factors (such as light, air pollution, climate). Clinically, it manifests as wrinkles, skin sagging, uneven skin tone, and decreased elasticity.
Dr. Jiang Min further explained that “cellular aging, mitochondrial dysfunction, decreased nutrient sensitivity, protein homeostasis imbalance, epigenetic modifications, telomere attrition, genomic instability, impaired intercellular communication, stem cell depletion, chronic inflammation, dysbiosis, and dysfunctional autophagy” are 12 characteristics of aging and also the mechanisms and potential targets for skin aging. There is evidence suggesting that fatigue and stress accelerate this process.
Professor Yu Wei from the School of Life Sciences at Fudan University also shared similar views on the mechanism of fatigue-induced aging. He believes that prolonged sleep deprivation and excessive fatigue can lead to hormonal imbalances and metabolic disorders in the body, while stressful events in life can cause elevated levels of adrenal cortex hormones, resulting in aging features in the skin.
Under the theme of “Calorie-Induced Aging Mechanisms Research,” Professor Yu Wei emphasized the mechanisms and significance of calorie restriction in skin anti-aging. Through research on oxidative stress, mitochondrial energy, and cellular damage, he further revealed potential approaches to slowing down the aging process.
It is evident that at the “2024 China Women’s Anti-Fatigue Aging Technology Forum,” experts from medical and research institutions such as Huashan Hospital affiliated with Fudan University and the School of Life Sciences at Fudan University provided scientific insights into the mechanisms behind “fatigue-induced aging.”
It is apparent that “fatigue-induced aging” is becoming a new research trend following “photoaging,” indicating that the scientific community is becoming more precise in their studies of anti-aging in the field of skincare.
CHANDO pioneers the “Anti-Fatigue Aging” Serum
It is worth noting that based on scientific research on fatigue-induced aging and consumer insights, CHANDO has identified three key points for combating fatigue-induced aging: cellular rejuvenation, layered advanced anti-aging, and multi-scene considerations. Therefore, at this forum, CHANDO unveiled a cutting-edge breakthrough in “Anti-Fatigue Aging” technology—the self-developed polar yeast HiMurchaSin® fermentation filtrate and cytosol, and proposed the concept of cellular rejuvenation for anti-fatigue aging and fundamental solutions for combating fatigue-induced aging.
Zou Yue, General Manager of CHANDO Research and Development Center, introduced that HiMurchaSin® fermentation filtrate and cytosol were developed using CHANDO’s fifth-generation intelligent fermentation technology. “The fifth-generation intelligent fermentation technology adopts digital research and development methods, allowing scientific mechanisms, ingredient technology, and skincare pain points to interact and influence each other, forming a closed loop.”
It is understood that HiMurchaSin® fermentation filtrate and cytosol are rich in 940 active small molecular components, providing different types of nutrients to directly replenish the deep layers of the skin. Among them, the relative content of adenosine in yeast cytosol accounts for 77% of the total content of metabolites, which can help cells replenish lost energy and promote cellular rejuvenation. Zou Yue stated, “By using the fifth-generation fermentation technology and unique fermentation processes, HiMurchaSin cytosol has enhanced permeability and absorption, reaching the deep layers of the skin, bidding farewell to fatigue-induced sagging.”
It is worth mentioning that CHANDO’s self-developed polar yeast HiMurchaSin® fermentation filtrate and cytosol have now been applied to CHANDO’s newly launched sixth-generation Serum, making it the first “Anti-Fatigue Aging” Serum in the Chinese cosmetics industry.
According to the CHANDO brand, based on precise insights into fatigue-induced anti-aging and technological innovations, the sixth generation of CHANDO’s serum has undergone a comprehensive upgrade in core ingredients, product efficacy, texture, and packaging. Each drop of Serum contains 200 million yeast cell Serum and 940 polar nutrient small molecules, achieving 8 times cellular rejuvenation to combat fatigue-induced aging. In addition, the product is scientifically formulated with ingredients such as 99% pure retinol, peptides, and tranexamic acid, enhancing its antioxidant capacity. Third-party human efficacy validation results show that after using the sixth-generation Serum, over 97% of the subjects recognized an immediate firming effect, and after 12 hours, skin elasticity increased by 10%.
In other words, CHANDO first conducted basic research on “fatigue-induced aging” and proposed the concept of “Anti-Fatigue Aging.” Then, based on target mechanisms and ingredient research, they put forward a solution for combating fatigue-induced aging. Finally, they implemented it in their iconic product, CHANDO’s sixth-generation serum, thereby achieving the translation of scientific research results. This also reflects the brand’s leading capabilities in multiple dimensions such as scientific research, innovation, and operations.
It is worth noting that according to a report by People’s Daily, during the forum, CHANDO announced its collaboration with the Institute of Nutrition and Health to jointly initiate a scientific research project on the characteristics and mechanisms of skin rejuvenation in Chinese women, continuously deepening the study of aging trends and causes among the Chinese population, and exploring scientific solutions.
CHANDO’s New Serum Leads the Hundred Billion Anti-Aging Market
As we all know, in January this year, the No. 1 document of the State Council in 2024 focused on the silver economy for the first time, explicitly proposing the development of the anti-aging industry and including “promoting the research and development of cosmetic raw materials, formulation, and production process design” in the guidelines. Guided by national policies, domestic and international beauty brands have been increasing their investment in scientific research on anti-aging and product layout.
According to CHAILEEDO, the annual average growth rate of the anti-aging market from 2017 to 2022 exceeded 10%. Based on this calculation, the scale of China’s skincare and anti-aging market is expected to reach 154 billion yuan in 2024. Undoubtedly, in the context of the booming anti-aging market, only brands with true scientific research capabilities can stand at the forefront. Clearly, CHANDO is prepared for this.
It is understood that CHANDO’s parent company, CHANDO Group, is guided by the principle of “prioritizing scientific research” and aims to use cutting-edge interdisciplinary technologies to innovatively develop world-class quality cosmetics. The group has developed and established six research platforms, including the Consumer Big Data Insights Platform, Oriental Dermatology Research Platform, Raw Material Screening and Development Platform, Formulation Technology Platform, Packaging Development Platform, and Six Senses and Six Personalities Testing Platform, to empower product technology.
The CHANDO Group Research and Development Center currently has a total of 141 researchers, bringing together top senior research experts from multiple countries. They have applied for a total of 458 patents (222 of which have been granted) and participated in 31 national standards, industry standards, and group standards. They have published a cumulative total of 175 scientific articles (65 of which are international papers).
It is worth mentioning that CHANDO Group’s research in the field of microbiology can be traced back to before 2013. Starting with the dream of having independently developed powerful anti-aging ingredients, they conducted research on microbial strains, multi-target research on anti-aging efficacy, fermentation process research, initiated metabolomic analysis and process research, and finally achieved formulation application. CHANDO has accumulated and built upon 11 years of research on polar yeast.
According to Zou Yue, “The CHANDO Group’s microbial fermentation research and development technology platform that gave birth to HiMurchaSin® polar yeast has applied for 30+ patents for Himalayan microbial fermentation research and published 10+ papers in domestic and international core journals.” This further proves the high level of scientific research and market leadership of CHANDO’s polar yeast HiMurchaSin.
Emphasizing scientific research and continuous innovation has been the key to CHANDO’s leading position in the Chinese cosmetics industry for over 20 years. This time, with in-depth research on “anti-fatigue aging” and the translation of scientific research results, the brand has once again led a new trend in the hundred billion anti-aging field.
