Perfect Diary has achieved another technological breakthrough.
On September 26th, the second-generation biomimetic membrane technology conference with the theme “Roots Anti-Aging, Renewal and Rebirth” was held in Shanghai by Perfect Diary. The upgraded second-generation Biotec™ technology made its debut, showcasing the new generation technology in Perfect Diary’s second-generation “biomimetic membrane” essence lipsticks and the Perfect Diary “biomimetic membrane” skincare series, officially unveiling their mystery.
The connection between technology and beauty has never been as profound as it is today. For beauty brands, technological innovation is not only a new trend in the beauty industry but also a crucial driving force for continuous brand advancement. Based on forward-looking insights into the consumer market, Perfect Diary is using technology to lead the integration of makeup and skincare, catering to the future trends in beauty.
Notably, in recent years, Perfect Diary’s parent company Yatsen Group has been strengthening its research layout, collaborating with 23 authoritative research institutions at home and abroad, achieving numerous research accomplishments, and publishing over 20 patents and articles related to anti-aging.
Breakthrough in the field of Chinese makeup and skincare, achieving “all-round anti-aging” for lip skin
The breakthrough in technological innovation reflects the further enhancement of the Perfect Diary brand power. It is understood that the all-new second-generation “biomimetic membrane” technology by Perfect Diary comes with three major upgrades. Compared to the first-generation patented pomegranate peptide complex, the content of revitalizing peptides has been increased by 50%, and the composition of biomimetic groups has also been optimized. Notably, the “Anti-Aging GPS” precise penetration technology represents a groundbreaking advancement in the anti-aging field. By precisely activating dermal stem cells for self-regeneration, it can achieve “external supplementation, internal promotion,” and bi-directionally create a biomimetic sebum membrane for the skin, thereby strengthening the epidermal barrier and repairing the basal membrane.

During the conference, Yatsen Group’s founder, chairman, and CEO, Huang Jinfeng, Perfect Diary’s global brand ambassador, Zhou Xun, and Yatsen Group’s Chief Scientific Officer & Perfect Diary’s Chief Scientific Officer, Cheng Jing, jointly unveiled the upgraded second-generation “biomimetic membrane” essence lipsticks. It is reported that this new product not only creates a biomimetic sebum membrane for the fragile barrier function of lip skin but also achieves a repair effect of 48.09% reduction in lip wrinkles in 1 day, 63.48% improvement in barrier repair and reduction of lip peeling and dryness in 2 weeks.
According to Cheng Jing, “The second-generation biomimetic membrane Biotec™ technology can precisely activate dermal stem cells for self-regeneration, thereby achieving ‘all-round anti-aging’ for lip skin, bringing a new breakthrough in the field of Chinese makeup and skincare.”

Moreover, as a lipstick product that integrates lipstick, lip essence, and lip mask, the second-generation “biomimetic membrane” essence lipstick combines new temperature-sensitive layering technology and color powder micro-buckling technology, providing consumers with a triple-layer color retention texture for easy external color protection, middle color locking, and bottom moisturizing color effects.
Solid technological innovation must withstand the test of effectiveness. During the conference, Cao Hua, Deputy Director of the Dermatology Department at Shanghai Jiao Tong University School of Medicine affiliated Ruijin Hospital, shared the clinical trial results of the second-generation “biomimetic membrane” essence lipstick, which underwent dual authoritative verification by Ruijin Hospital and SGS International Testing Agency – 48.09% reduction in wrinkles in 1 day, significant improvement in lip moisture content and plumpness in 2 weeks.

In addition to the second-generation “biomimetic membrane” essence lipstick, Perfect Diary also unveiled skincare line products incorporating the second-generation biomimetic membrane Biotec™ technology, including essence cream, essence water, essence eye cream, and essence face mask products. The “biomimetic membrane” essence cream, enhanced by the second-generation biomimetic membrane Biotec™ technology, also features the patented 317 dual collagen, anti-gravity seaweed essence, and exclusive fermented golden skin renewal factor, offering three exclusive “black technologies.”
The patented 317 dual collagen and anti-gravity seaweed essence ingredients effectively replenish and promote dermal proteins, stimulating a 138% increase in type I collagen production in the dermis over 24 hours and a 117% improvement in dermal firmness. Additionally, the application of the exclusive fermented golden skin renewal factor synergistically promotes permeation to achieve brightening effects.
Based on changes in market demand and consumer trends, it can be said that the second-generation Biotec™ not only brings about a technological upgrade but also represents another scientific practice of Perfect Diary’s concept of leading makeup and skincare integration through technology.
Headline: Perfect Diary Collaborates with Global Experts to Achieve New Anti-Aging Breakthroughs Published in Two Prestigious Scientific Journals
Apart from launching new products, Perfect Diary unveiled groundbreaking research on anti-aging at the event. It is known that Perfect Diary, in collaboration with the joint laboratory of Sun Yat-sen University, has had two related academic papers published in two world-renowned scientific journals, “Nature Medicine” and “Science Bulletin.” This move has set a new direction for the future of global skin anti-aging.

During the event, Professor Zhang Hongbo, a professor and doctoral supervisor at the Stem Cell and Regenerative Medicine Research Center of Sun Yat-sen Medical College, who is one of the key contributors to the implementation of the two academic achievements, mentioned, “In response to the concerns in the academic community regarding aging, our team hopes to collaborate with other scientists from the ‘Aging Biomarker Consortium (ABC)’ to establish an accurate biological assessment system for the human body by integrating relevant biological data. In the future, we hope to collaborate with anti-aging research institutions worldwide to collectively establish a set of biological markers for human aging.”

Professor Zhang Hongbo also shared cutting-edge research on anti-aging during the event. He emphasized, “As we age, the regenerative capacity of stem cells diminishes, leading to a loss of skin elasticity and the formation of wrinkles. Therefore, maintaining the activity of stem cells is crucial for delaying skin aging.”

At the event, Dr. Jeffrey Robens, Director of Community Engagement at Nature Portfolio and Chief Lecturer of the Nature Masterclass-Expert Classroom, highly praised Perfect Diary’s vision for anti-aging research and the achievements brought by Professor Zhang Hongbo in the field of anti-aging. He stated that the academic work published by Nature Medicine has developed a comprehensive framework of aging biomarkers, which will enhance people’s profound understanding of aging and open up new perspectives for more institutions and scholars.

Furthermore, Professor Reinhold H. Dauskardt from the BioDesign Institute of Stanford University School of Medicine shared about the various impacts of the sebum membrane on skin health starting from the structure and tissue of lip skin. He mentioned, “Compared to facial skin, lip skin lacks a sebum membrane, making it more prone to dryness and wrinkling. By innovating with technological advancements in lipstick products to create a sebum membrane for the lips, it can help make the lips more moisturized and healthy, an area that Perfect Diary has been dedicated to exploring.”
It is evident that this sharing not only affirms the professionalism and innovation of Perfect Diary’s second-generation “biomimetic membrane” Biotec™ technology research but also acknowledges the practicality of the skincare benefits of the second-generation “biomimetic membrane” essence lipstick.
A bold investment of 500 million yuan, Perfect Diary leads the integration of makeup and skincare.
Currently, the fusion of technology and beauty is profoundly changing the operational methods of the beauty industry, propelling many beauty companies and brands to new heights. However, technological innovation is never a shortcut, nor can it tolerate any falsity. Rooted in solid technological foundations, Perfect Diary’s parent company, Yatsen Group, consistently maintains sustained investment.
It is reported that over the past few years, Yatsen Group has invested over 500 million yuan in research and development. Huang Jinfeng stated, “Behind an excellent product lies the meticulous efforts of the enterprise and brand.”
In fact, seizing the new high ground of “makeup and skincare integration” through technological innovation, Perfect Diary has accelerated its pace. Just at the end of May this year, the Yatsen Global Innovation Research Center was officially unveiled in Shanghai. It is understood that the initial investment of the Yatsen Global Innovation Research Center exceeded 80 million yuan, with a building area of up to 4,000 square meters.
In addition to substantial investment, the Yatsen Global Innovation Research Center is equipped with a variety of fully functional research laboratories including cutting-edge, formulation, analysis, microbiology, sensory, clinical, packaging, emotional testing labs, and pilot amplification, achieving full-chain management of research and development. It is also equipped with over 300 internationally top-tier devices such as flow cytometers, multifunctional enzyme immunoassay analyzers, facial analysis imaging systems, and more. Furthermore, Yatsen Group also established the Yatsen Biotechnology, a global advanced beauty factory integrating research and development, manufacturing, and quality control last year.
These two major strategic deployments, along with the Toulouse Research Center in France and the Guangzhou Research Center, jointly construct Yatsen Group’s global research and development layout, further perfecting the complete ecological chain from cutting-edge technological research to advanced manufacturing. By steadfastly focusing on research, this year Perfect Diary also released the industry’s first “makeup and skincare integration” research report, sharing the brand’s latest achievements and product development methodologies in leading the integration of technology and skincare.

As of the end of 2023, the sales of Perfect Diary’s “biomimetic membrane” essence lipstick series exceeded one billion yuan, and in 2024, it topped multiple lipstick rankings on various platforms. This includes ranking No. 1 in the Q1 Tmall lipstick new product ranking (dominating the top three for 2 weeks), ranking No. 1 in the popular matte lipstick list and the highly praised list on Douyin Mall. Additionally, the product has won several industry-recognized beauty awards, such as the People’s Network National Consumer Word-of-Mouth Product and the WWD International Beauty Industry Awards, receiving widespread acclaim from consumers.
It is the continuous breakthroughs in research that have enabled Perfect Diary to precisely seize the new high ground of “makeup and skincare integration” and become a professional leader in the field of makeup and skincare technology. Looking to the future, Perfect Diary states that it will adhere to the concept of technology leading “makeup and skincare integration,” continuously introduce more high-quality and innovative beauty products, and embark on a new journey for consumers that emphasizes both makeup and skincare.





